Learn vocabulary, terms, and more with flashcards, games, and other study tools. It is defined as the volume in which the amount of drug would need to be uniformly distributed to. The volume of distribution v d, also known as apparent volume of distribution, is used to quantify the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing. This tutorial deals with basic concepts of volume of distribution, the second most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. The volume distribution is the theoretical volume into which for example a drug is distributed into the body.
Halflife, volume of distribution, and therapeutic drug monitoring. It is a major determinant of halflife and dosing frequency of a drug. The apparent volume is the volume into which the drug is known to distribute in the. Volumes of distribution should be determined early in drug development programmes and those having a large volume of distribution may be selected to obtain a long terminal halflife even for drugs. Significance of the apparent volume of distribution answers. The volume of distribution vd, also known as apparent volume of distribution, is a pharmacologic term used to quantify the distribution of a drug throughout the body after oral or intravenous dosing. This lesson will discuss the definition and significance of volume of. For a similar log p, a basic molecule will tend to exhibit higher volume of distribution than a neutral molecule. Volume of distribution pharmacology lect 5 youtube. In pharmacology, the volume of distribution v d, also known as apparent volume of distribution, literally, volume of dilution is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. The volume of distribution is a hypothetical amount, meaning that it is not a real volume, but instead is a concept of volume. Volume of distribution is one of the most important pharmacokinetic properties of a drug candidate. It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration. Volume of distribution an overview sciencedirect topics.
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